As X-Factor unloads their hopes, fears and darkest secrets to Doc Samson, Jamie Madrox decides to gather up his stray dupes. The trouble is, two don't want to go quietly: the married priest and the agent of S.H.I.E.L.D.! And when Hydra comes calling, will Jamie become their secret weapon? With Mutant Town under siege thanks to the terrorist X-Cell, X-Factor races the clock to keep every former mutant from being imprisoned. What an awful time for the Isolationist to strike! Then, after the events of MESSIAH COMPLEX, X-Factor is a shambles. Jamie is a basket case; Wolfsbane quits but won't say why; and Layla is trapped in the future, in the middle of the Summers Rebellion! Plus: Quicksilver's life takes a dramatic turn! Collecting X-FACTOR (2006) #13-24 and #28-32, X-FACTOR: THE QUICK AND THE DEAD #1, and X-FACTOR SPECIAL: LAYLA MILLER #1.